The mighty San Juan River runs through an enormous wildlife reserve which is positively teeming with life. This largely inaccessible swathe of wilderness once carried Conquistadores and pirates into Nicaragua, but now lies dormant. It offers one of your best chances to see the Jaguar, Tapir and Manatee and guarantees close encounters with Sloths, Monkeys, Macaws and Toucans to name but a few.